What version of Baldur's Gate & Tales of the Sword Coast are you using? What type of install did you select (full, minimum, custom)? You have the official patch for the version of the game you are using? You aren't using Tutu, or any mods right?
That looks very weird to me. I've never seen anything like it. You don't have any strange processes going on in the background, or doing some odd thing like playing from a portable drive or whatever?
I'd definitely post on the Bioware forums and ask there. Kevin Lynch is the moderator on the Bioware BG/BG2 forums and he usually answers most tech help question. He's been there forever too, and he really knows his stuff. He's probably seen just about everything. If anyone could help you, then he could.