To prevent them starting conversation if not in party, use
NumTimesTalkedTo(0)
trigger as a condition for initiating dialogue. So once you talk to the NPC once, the NPC will not initiate again.
Make sure that in your D file there is no SetNumTimesTalkedTo(0) or something like that, which will make the NPC behave as if you had neve talked to her.
For the Bio when copying your CRE to the override folder, use
SAY BIO ~biography~
in the TP2 file.
For the instant kill, check her items, and edit her CRE
not sure about what causes that. Uberweapon? Lol, remember that she converting CHR to CRE I think causes all the items to remain on the NPC