Bioware has a beta patch to address a problem with the last "official" ToB patch 26498:
This BETA patch is being provided to fix a particular issue with the Throne of Bhaal 26498 patch. If you are having a problem with save and load times noticeably increasing, the new Throne of Bhaal 26499 BETA patch has been found to resolve the problem.
The only time I've noticed the dramatically increased save/load times is with the
Smarter Mages component of SCS installed. DavidW and pro5 can't seem to pin down what might be causing this within SCS. So I'm wondering if it's theoretically possible to install this patch with EasyTutu, either before or after the Tutu conversion.